DIAGNOSIS OF CYTOMEGALOVIRUS INFECTION IN BABY
Cytomegalovirus infection in pregnancy can cause serious disease in baby in utero & infants. 1-3% of women are infected during pregnancy & in 1 out of every 2 cases, the infection is passed on to the fetus & causes malformation. In immunocompromised patients CMV infection can be still more severe.
Detection of CMV specific Igm is an essential tool for diagnosis & follow up of acute infection, A rise in anti-CMV IGM titre may be indicative of recent infection. Primary infection only causes disease & malformation in baby.
For differentiation of primary infection as opposed to reactivation, ie chronic infection is the solution. It can be detected by CMV Igm avidity test.
Igm avidity testing is recommended to differentiate between primary infection & reactivation. Thus a positive Igm & low avidity suggest primary, or recent infection. Whereas a high avidity Igm indicates either Igm persistence or reactivation (chronic infection)
For example Mrs.Beena had
This shows child will be free of CMV infection
Last 1000 High Risk Births Ananlysed Antenatal Care at Life Care Centre
Delivery: Pushpanjali Medical Centre,
Max Balaji Hospital (2008 Dec)
| Singletons | Twins |
|---|---|
| Mean gestational – 39 Weeks Age (Weeks) | 35.7 |
| % Very Preterm – 1.7 (<33 weeks) | 16 |
| Preterm (<37 weeks) – 9.43 | 50.9 |
| Mean birth weight – 3.06 | 2.3 |
| % Very low birth weight – 1.1 (<1500) | 10.1 |
| % Low Birth weight (2500 gm) – 6.00%
% LSCS – 42% |
72.24 |
| % PIH – 27% Hellp Syndrome – 0.3% |
|
| Anaemia – at Ist Visit – 58% at delivery – 27% |
|
| PPH - 4% |
Condition for Cesarean Section
